Los suplementos potenciadores del Oxido Nitrico son potencialmente peligrosos [Estudio]

Havo · #1 08-05-2011, 17:07

Un grupo de investigadores del Reino Unido creen que estos suplementos pueden ser peligrosos, y son moralmente cuestionables para compañías de suplementos que los venden.

Cita:

Abstract

Background: Considerable interest has been shown by athletes and scientists in the potential for nitric oxide and associated vasodilators to enhance performance. This study aims to explore potential misuse of vasodilators by the athletes, and to highlight the growing concern over these agents.

Methods: Retrospective analyses of anonymous inquiries recorded in the Drug Information DatabaseTM (DIDTM) between January 2006 and June 2008 (inclusive). In this 30-month period, the DIDTM recorded 198,023 inquiries, of which 118,724 were UK Licensed Pharmaceutical products with a further 79,299 inquiries made for substance not found in the database.

Results: Phosphodiesterase type 5 (PDE-5) inhibitors, dominated by Viagra®, ranked 16th among the substance groups. The proportion of the inquiries made regarding PDE-5 inhibitors, especially in comparison to antibiotics, painkillers or alcohol, appears to be above the level that would normally be expected from medical need. No significant change in the months leading up to the Beijing Olympics was observed. On the contrary, the Nitric/Nitrate group showed a notable increase between 2006-2007 and 2008, suggesting a potential increase in interest in using nitric oxide among athletes.

Conclusions: With patents recently filed for the use of agents containing sodium nitrite/nitrate to enhance blood flow for performance enhancement in sport, coupled with anecdotal evidence from internet athlete forums and media, there is a concern that athletes may endanger their health by using vasodilators to enhance athletic performance.

PDE- 5 inhibitors or chemicals in the nitrate/nitrate group are currently not prohibited or tested for by the doping control agencies but some are highly dangerous to health and can lead to cardiovascular collapse, coma and death. Its promotion among athletes as a performance enhancing supplement is ethically and medically questionable.

* AndreaPetróczi and DeclanPNaughton, Authors.

Havo · #2 08-05-2011, 17:14

Hasta se especula la posibilidad de que la mezcla de creatina con potenciadores de NOX pueda ser cancerigena.

Anthony Roberts lo comenta en su Blog .

Cita:

Creatine + Nitrite = Carcinogen

Back in 1971, a scientist by the almost impossibly cool name of Archer (M.C. Archer, technically) performed a little study whereby he examined the interactions of nitrite with creatine and creatinine. The result of that study was a very brief, very forgotten, two page paper. Since creatine and creatinine are both present in the human body, both nitrates and nitrites are frequently used in food production, it’s logical to take an interest in their interaction. The average daily intake of Nitrate in the human diet is estimated at 75 milligrams (mgs). After it’s consumed, roughly 5% of the nitrate (NO3) taken in by healthy adults is further reduced to nitrite (NO2) by bacteria in saliva, and an additional amount is then converted in the stomach. Most people consume a couple of grams worth (2,000mgs) of creatine each day from a typical diet. So what happens when an excess of creatine and nitrite/nitrate get together in an acidic environment, similar to what might be found in…the belly of a human being?